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pentobarbital will reduce the level or impact of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Prevent coadministration of lefamulin with potent or average CYP3A inducers Except the benefit outweighs hazards. Watch for lessened efficacy.Induction of microsomal enzymes by this drug, may well short